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Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.

Bioorganic & medicinal chemistry - 15 Apr 2021

Yang Yueying, Xiang Ke, Sun Dejuan, Zheng Mengzhu, Song Zhuorui, Li Mingxue, Wang Xuanbin, Li Hua, Chen Lixia

Abstract excerpt

Isocitrate dehydrogenase (IDH) is one key rate-limiting enzyme in the tricarboxylic acid cycle, which is related to various cancers. Tomatillo (Physalis ixocarpa), a special tomato, is widely consumed as nutritious vegetable in Mexico, USA, etc. As a rich source for withanolides, the fruits of P. ixocarpa were investigated, leading to the isolation of 11 type-A withanolides including 4 new ones (1 is an...

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PMID: 33735687
DOI: 10.1016/j.bmc.2021.116095

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