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Withaferin A decreases glycolytic reprogramming in breast cancer

4 Oct 2024

Abstract excerpt

Reprogrammed glucose metabolism is considered as the hallmark of cancer with therapeutic implications. Phytocompounds have potential to inhibit cancer metabolism. Here, we tested the ability of Withaferin A (WA), a withanolide derived from Withania somnifera, in modulating cancer metabolism. The assessed effect of WA on aerobic glycolysis in breast cancer cell lines showed that WA decreases the glucose uptake,...

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PMID: 39366987
DOI: 10.1038/s41598-024-72221-5

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