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Article

Physangulidine A, a Withanolide from <i>Physalis angulata</i>, Perturbs the Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer Cells

27 Dec 2012

Abstract excerpt

Recently, our group reported the discovery of three new withanolides, physangulidines A-C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of the three new constituents, are described. It was found that 1 significantly reduces survival in clonogenic assays for two hormone-independent prostate cancer cell lines. Flow cytometry and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23270478
DOI: 10.1021/np300457g

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