Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

1 Jan 2008

Abstract excerpt

A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Drug Discovery Methods
Share to Phytochemicals and Medicinal Plants

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18239318
DOI: 10.1248/cpb.56.234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Withangulatin I, a New Cytotoxic Withanolide from Physalis angulataPMID 18239318Read ↗

Withanolides: Promising candidates for cancer therapySemantic proximity Read ↗

Physangulidine A, a Withanolide from <i>Physalis angulata</i>, Perturbs the Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer CellsSemantic proximity Read ↗

Differential Activities of the Two Closely Related Withanolides, Withaferin A and Withanone: Bioinformatics and Experimental EvidencesSemantic proximity Read ↗

Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma CellsSemantic proximity Read ↗

Withaferin A, a Cytotoxic Steroid from <i>Vassobia breviflora</i>, Induces Apoptosis in Human Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)Semantic proximity Read ↗

In silico evaluation of pharmacokinetics properties of withanolides and simulation of their biological activities against Alzheimer’s diseaseSemantic proximity Read ↗

Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.Semantic proximity Read ↗

Withanone-Rich Combination of Ashwagandha Withanolides Restricts Metastasis and Angiogenesis through hnRNP-KSemantic proximity Read ↗

In silico screening and identifying phytoconstituents of Withania somnifera as potent inhibitors of BRCA1 mutants: A therapeutic against breast cancer.Semantic proximity Read ↗

Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of ActionSemantic proximity Read ↗

Antiproliferative Activity of Withanolides against Human Breast Cancer Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.