Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome-wide association study reveals two genes that influence mismatch negativity.

Cell reports - 16 Mar 2021

Bhat Anjali, Irizar Haritz, Thygesen Johan Hilge, Kuchenbaecker Karoline, Pain Oliver, Adams Rick A, Zartaloudi Eirini, Harju-Seppänen Jasmine, Austin-Zimmerman Isabelle, Wang Baihan, Muir Rebecca, Summerfelt Ann, Du Xiaoming Michael, Bruce Heather, O'Donnell Patricio, Srivastava Deepak P, Friston Karl, Hong L Elliot, Hall Mei-Hua, Bramon Elvira

Abstract excerpt

Mismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. Here, we perform a transcriptome-wide association study of 728 individuals, which reveals 2 genes (FAM89A and ENGASE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Ventricles
Share to Electrophysiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Intrinsically Disordered Proteins

Share to Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase

Share to Memory, Short-Term

Share to Neurotransmitter Agents

Share to Receptors, Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 33730571
DOI: 10.1016/j.celrep.2021.108868
PMCID: PMC7972991

Genes

ENGASE
FAM89A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-wide association study reveals two genes that influence mismatch negativity.PMID 33730571Read ↗

Synaptic function and sensory processing in ZDHHC9-associated neurodevelopmental disorder: a mechanistic accountSemantic proximity Read ↗

Heritability and reliability of P300, P50 and duration mismatch negativity.Semantic proximity Read ↗

Genomic substrates of neurophysiological endophenotypes: where we've been and where we're going.Semantic proximity Read ↗

Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures.Semantic proximity Read ↗

Association analysis of 94 candidate genes and schizophrenia-related endophenotypes.Semantic proximity Read ↗

The endophenotype concept in psychiatry: etymology and strategic intentions.Semantic proximity Read ↗

COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.Semantic proximity Read ↗

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds.Semantic proximity Read ↗

Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic lociSemantic proximity Read ↗

Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms.Semantic proximity Read ↗

Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report.Semantic proximity Read ↗

Knowns and unknowns for psychophysiological endophenotypes: integration and response to commentaries.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.