Article
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.
Molecular psychiatry - 1 Apr 2025
Cai Na, Verhulst Brad, Andreassen Ole A, Buitelaar Jan, Edenberg Howard J, Hettema John M, Gandal Michael, Grotzinger Andrew, Jonas Katherine, Lee Phil, Mallard Travis T, Mattheisen Manuel, Neale Michael C, Nurnberger John I, Peyrot Wouter J, Tucker-Drob Elliot M, Smoller Jordan W, Kendler Kenneth S
Abstract excerpt
Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1-4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute to convergent disease etiologies and the unique genetic factors that distinguish between disorders [4, 5]. This information can illuminate the biological mechanisms underlying...
Read the complete abstract on PubMedTopics
- Humans
- Mental Disorders
- Genetic Predisposition to Disease
- Molecular Biology