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Variability in digestive and respiratory tract Ace2 expression is associated with the microbiome

16 Mar 2021

Abstract excerpt

COVID-19 (coronavirus disease 2019) patients exhibiting gastrointestinal symptoms are reported to have worse prognosis. Ace2 (angiotensin-converting enzyme 2), the gene encoding the host protein to which SARS-CoV-2 spike proteins bind, is expressed in the gut and therefore may be a target for preventing or reducing severity of COVID-19. Here we test the hypothesis that Ace2 expression in the gastrointestinal and...

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PMID: 33725024
DOI: 10.1371/journal.pone.0248730

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