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Article

EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease.

Journal of neuro-oncology - 1 Sept 2023

Alzate Juan Diego, Mullen Reed, Mashiach Elad, Bernstein Kenneth, De Nigris Vasconcellos Fernando, Rotmann Lauren, Berger Assaf, Qu Tanxia, Silverman Joshua S, Golfinos John G, Donahue Bernadine R, Kondziolka Douglas

Abstract excerpt

PURPOSE: Patients with EGFR-mutated NSCLC represent a unique subset of lung cancer patients with distinct clinical and molecular characteristics. Previous studies have shown a higher incidence of brain metastases (BM) in this subgroup of patients, and neurologic death has been reported to be as high as 40% and correlates with leptomeningeal disease (LMD). METHODS: Between 2012 and 2021, a retrospective review of...

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Source

Identifiers

PMID: 37691032
DOI: 10.1007/s11060-023-04442-z

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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