Article
Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function.
eLife - 15 Mar 2021
Reay William R, El Shair Sahar I, Geaghan Michael P, Riveros Carlos, Holliday Elizabeth G, McEvoy Mark A, Hancock Stephen, Peel Roseanne, Scott Rodney J, Attia John R, Cairns Murray J
Abstract excerpt
Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven druggable biochemical traits, with further evidence of a causal relationship between increased fasting glucose and diminished lung function. Moreover, we developed polygenic scores...
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