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Transcriptional analysis of islets of Langerhans from organ donors of different ages

12 Mar 2021

Abstract excerpt

Insulin secretion is impaired with increasing age. In this study, we aimed to determine whether aging induces specific transcriptional changes in human islets. Laser capture microdissection was used to extract pancreatic islet tissue from 37 deceased organ donors aged 1-81 years. The transcriptomes of the extracted islets were analysed using Ion AmpliSeq sequencing. 346 genes that co-vary significantly with age...

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PMID: 33711030
DOI: 10.1371/journal.pone.0247888

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