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A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity

1 Jan 2021

Abstract excerpt

African swine fever virus (ASFV) is the causal agent of a fatal disease of domestic swine for which no effective antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses. In this study, we conducted in silico screening against the colchicine binding site (CBS) of tubulin and found three new compounds with anti-ASFV activity. The...

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PMID: 33706677
DOI: 10.1080/22221751.2021.1902751

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