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A Two-Gene Signature for Tuberculosis Diagnosis in Persons With Advanced HIV

22 Feb 2021

Abstract excerpt

Background: Transcriptomic signatures for tuberculosis (TB) have been proposed and represent a promising diagnostic tool. Data remain limited in persons with advanced HIV. Methods: We enrolled 30 patients with advanced HIV (CD4 <100 cells/mm3) in India; 16 with active TB and 14 without. Whole-blood RNA sequencing was performed; these data were merged with a publicly available dataset from Uganda (n = 33; 18 with...

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PMID: 33692804
DOI: 10.3389/fimmu.2021.631165

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