Article
Cell-based methods for the identification of MYC-inhibitory small molecules.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Burkhart Catherine A, Haber Michelle, Norris Murray D, Gudkov Andrei V, Nikiforov Mikhail A
Abstract excerpt
Oncoproteins encoded by dominant oncogenes have long been considered as targets for chemotherapeutic intervention. However, oncogenic transcription factors have often been dismissed as "undruggable." Members of Myc family of transcription factors have been identified as promising targets for cancer chemotherapy in multiple publications reporting the requirement of Myc proteins for maintenance of almost every type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.