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Article

Effect of Tumor Necrosis Factor Inhibitor Therapy on Osteoclasts Precursors in Ankylosing Spondylitis.

PloS one - 1 Jan 2015

Perpétuo Inês P, Raposeiro Rita, Caetano-Lopes Joana, Vieira-Sousa Elsa, Campanilho-Marques Raquel, Ponte Cristina, Canhão Helena, Ainola Mari, Fonseca João E

Abstract excerpt

INTRODUCTION: Ankylosing Spondylitis (AS) is characterized by excessive local bone formation and concomitant systemic bone loss. Tumor necrosis factor (TNF) plays a central role in the inflammation of axial skeleton and enthesis of AS patients. Despite reduction of inflammation and systemic bone loss, AS patients treated with TNF inhibitors (TNFi) have ongoing local bone formation. The aim of this study was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26674064
DOI: 10.1371/journal.pone.0144655
PMCID: PMC4682624

Genes

TNF
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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