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SERPINB5 Genetic Variants rs2289519 and rs2289521 are Significantly Associated with Gallbladder Cancer Risk.

DNA and cell biology - 1 May 2021

Mahananda Biswaheree, Vinay J, Palo Ananya, Singh Ayaskanta, Sahu Saroj Kanta, Singh Shivaram Prasad, Dixit Manjusha

Abstract excerpt

Serine protease inhibitor b5 (SERPINB5) is a tumor suppressor gene that plays a critical role in various cellular processes. In gallbladder cancer (GBC), SERPINB5's aberrant expression is reported but its role in genetic predisposition is not known. We enrolled 270 cases and 296 controls and genotyped them for single nucleotide polymorphisms (SNPs) using direct DNA sequencing, followed by genotype-phenotype...

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PMID: 33691472
DOI: 10.1089/dna.2021.0056

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