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Article

Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.

Acta neuropathologica communications - 8 Mar 2021

Liu Xiaodan, Wang Qilong, Yang Ying, Stewart Tessandra, Shi Min, Soltys David, Liu Genliang, Thorland Eric, Cilento Eugene M, Hou Yiran, Liu Zongran, Feng Tao, Zhang Jing

Abstract excerpt

Peripheral biomarkers indicative of brain pathology are critically needed for early detection of Parkinson's disease (PD). In this study, using NanoString and digital PCR technologies, we began by screening for alterations in genes associated with PD or atypical Parkinsonism in erythrocytes of PD patients, in which PD-related changes have been reported, and which contain ~ 99% of blood α-synuclein. Erythrocytic...

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Source

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Identifiers

PMID: 33685516
DOI: 10.1186/s40478-021-01133-6
PMCID: PMC7941904

Genes

CHCHD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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