Article
Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia.
Molecular pain - 1 Jan 2000
Nishizawa Daisuke, Iseki Masako, Arita Hideko, Hanaoka Kazuo, Yajima Choku, Kato Jitsu, Ogawa Setsuro, Hiranuma Ayako, Kasai Shinya, Hasegawa Junko, Hayashida Masakazu, Ikeda Kazutaka
Abstract excerpt
BACKGROUND: Human twin studies and other studies have indicated that chronic pain has heritability that ranges from 30% to 70%. We aimed to identify potential genetic variants that contribute to the susceptibility to chronic pain and efficacy of administered drugs. We conducted genome-wide association studies (GWASs) using whole-genome genotyping arrays with more than 700,000 markers in 191 chronic pain patients...
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