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Article

Next generation sequencing of RB1gene for the molecular diagnosis of ethnic minority with retinoblastoma in Yunnan.

BMC medical genetics - 23 Nov 2020

Zhang Zhen, Xiao Yi-Shuang, Shen Ru, Jiang Hong-Chao, Tan Li, Li Ren-Qiu, Yang Xiao-Hong, Gu Huai-Yu, He Wen-Ji, Ma Jing

Abstract excerpt

BACKGROUND: Retinoblastoma is a rare intraocular malignancy and typically initiated by inactivating biallelic mutations of RB1 gene. Each year, ~ 8000 children worldwide are diagnosed for retinoblastoma. In high-income countries, patient survival is over 95% while low-income countries is ~ 30%.If disease is diagnosed early and treated in centers specializing in retinoblastoma, the survival might exceed 95% and...

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Identifiers

PMID: 33225895
DOI: 10.1186/s12881-020-01150-7
PMCID: PMC7682003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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