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Article

Sequestosome 1/p62 enhances chronic skin inflammation.

The Journal of allergy and clinical immunology - 1 Jun 2021

Sukseree Supawadee, Bakiri Latifa, Palomo-Irigoyen Marta, Uluçkan Özge, Petzelbauer Peter, Wagner Erwin F

Abstract excerpt

BACKGROUND: The molecular control of inflammation and epidermal thickening in skin lesions of patients with atopic dermatitis (AD) is not known. Sequestosome 1/p62 is a multifunctional adapter protein implicated in the control of key regulators of cellular homeostasis, such as proinflammatory and mechanistic target of rapamycin signaling. OBJECTIVE: We sought to determine whether p62 plays a role in the cutaneous...

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Identifiers

PMID: 33675820
DOI: 10.1016/j.jaci.2021.02.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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