Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.

Nature - 15 Sept 2005

Zenz Rainer, Eferl Robert, Kenner Lukas, Florin Lore, Hummerich Lars, Mehic Denis, Scheuch Harald, Angel Peter, Tschachler Erwin, Wagner Erwin F

Abstract excerpt

Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity. Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression of JunB, a gene localized in the psoriasis susceptibility region PSORS6. Likewise, inducible epidermal deletion of JunB and its functional companion c-Jun in adult mice leads (within two weeks) to a phenotype resembling the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotaxis
Share to Arthritis, Psoriatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Epidermis

Share to Genes, jun

Share to Proto-Oncogene Proteins c-jun

Share to Receptors, Tumor Necrosis Factor, Type I

Share to S100 Proteins

Source

Identifiers

PMID: 16163348
DOI: 10.1038/nature03963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.PMID 16163348Read ↗

Signalling in inflammatory skin disease by AP-1 (Fos/Jun).Semantic proximity Read ↗

Role of IL-17A signalling in psoriasis and associated bone loss.Semantic proximity Read ↗

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin diseaseSemantic proximity Read ↗

RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation.Semantic proximity Read ↗

Increased JunB mRNA and Protein Expression in Psoriasis Vulgaris LesionsSemantic proximity Read ↗

TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.Semantic proximity Read ↗

JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skinSemantic proximity Read ↗

Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.Semantic proximity Read ↗

NF-κB-c-Rel in psoriasis: genetic susceptibility, immunopathogenic circuits, and emerging therapeutic opportunities.Semantic proximity Read ↗

Sequestosome 1/p62 enhances chronic skin inflammation.Semantic proximity Read ↗

A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model.Semantic proximity Read ↗

The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.