Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults

7 Sept 2022

Abstract excerpt

DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Disease Management Strategies
Share to Epigenetics and DNA Methylation
Share to Frailty in Older Adults

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36071044
DOI: 10.1038/s41467-022-32893-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adultsPMID 36071044Read ↗

Epigenome‐wide analysis of frailty: Results from two European twin cohortsSemantic proximity Read ↗

Frailty and Biological AgeSemantic proximity Read ↗

Epigenetic age acceleration links atherogenic dyslipidaemia, inflammageing and frailty with adverse cardiovascular outcomes in older adults (UFO): a lipid-metabolome and epigenetic clock analysisSemantic proximity Read ↗

Implementing Precision Medicine in Human Frailty through Epigenetic BiomarkersSemantic proximity Read ↗

Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty RiskSemantic proximity Read ↗

MultiAge: A New Multidimensional Biomarker of Biological Age Derived from Comprehensive Phenotypic and Molecular ProfilingSemantic proximity Read ↗

An epigenetic biomarker of aging for lifespan and healthspanSemantic proximity Read ↗

An epigenetic biomarker of aging for lifespan and healthspanSemantic proximity Read ↗

Tobacco smoking and smoking-related DNA methylation are associated with the development of frailty among older adultsSemantic proximity Read ↗

Frailty is associated with the epigenetic clock but not with telomere length in a German cohortSemantic proximity Read ↗

Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult malesSemantic proximity Read ↗

The epigenetic landscape of age-related diseases: the geroscience perspective.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.