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Article

A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups.

PloS one - 1 Jan 2021

Höhle Daniël, van Rooij Kim, Bloemers Jos, Pfaus James G, Michiels Frits, Janssen Paddy, Claassen Eric, Tuiten Adriaan

Abstract excerpt

Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations of Single-Nucleotide Polymorphism (SNPs) in large samples. We developed a novel method to produce PPS models for small samples sizes. The set of SNPs is first filtered on those known to be relevant in biological pathways involved in a clinical condition, and then further filtered...

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PMID: 33667227
DOI: 10.1371/journal.pone.0246828
PMCID: PMC7935233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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