Article
Downregulation of death receptor 4 is tightly associated with positive response of EGFR mutant lung cancer to EGFR-targeted therapy and improved prognosis.
Theranostics - 1 Jan 2021
Zhang Shuo, Chen Zhen, Shi Puyu, Fan Songqing, He Yong, Wang Qiming, Li Yixiang, Ramalingam Suresh S, Owonikoko Taofeek K, Sun Shi-Yong
Abstract excerpt
Death receptor 4 (DR4), a cell surface receptor, mediates apoptosis or induces inflammatory cytokine secretion upon binding to its ligand depending on cell contexts. Its prognostic impact in lung cancer and connection between EGFR-targeted therapy and DR4 modulation has not been reported and thus was the focus of this study. Methods: Intracellular protein alterations were measured by Western blotting. Cell...
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