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Article

Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.

Molecular cancer research : MCR - 1 Oct 2021

Qian Guoqing, Guo Jianping, Vallega Karin A, Hu Changjiang, Chen Zhen, Deng Yunfu, Wang Qiming, Fan Songqing, Ramalingam Suresh S, Owonikoko Taofeek K, Wei Wenyi, Sun Shi-Yong

Abstract excerpt

Expression of programmed death-ligand 1 (PD-L1) on cancer cells is a critical mechanism contributing to immunosuppression and immune escape. PD-L1 expression may also affect therapeutic outcomes of epidermal growth factor receptor (EGFR)-targeted therapy (e.g., with osimertinib/AZD9291) against EGFR-mutant non-small cell lung cancers (NSCLC) and can even be altered during the treatment albeit with largely...

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PMID: 34183449
DOI: 10.1158/1541-7786.MCR-21-0147
PMCID: PMC8492505

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