Article
Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours.
Nature communications - 3 Mar 2021
Custers Lars, Khabirova Eleonora, Coorens Tim H H, Oliver Thomas R W, Calandrini Camilla, Young Matthew D, Vieira Braga Felipe A, Ellis Peter, Mamanova Lira, Segers Heidi, Maat Arie, Kool Marcel, Hoving Eelco W, van den Heuvel-Eibrink Marry M, Nicholson James, Straathof Karin, Hook Liz, de Krijger Ronald R, Trayers Claire, Allinson Kieren, Behjati Sam, Drost Jarno
Abstract excerpt
Malignant rhabdoid tumour (MRT) is an often lethal childhood cancer that, like many paediatric tumours, is thought to arise from aberrant fetal development. The embryonic root and differentiation pathways underpinning MRT are not firmly established. Here, we study the origin of MRT by combining phylogenetic analyses and single-cell mRNA studies in patient-derived organoids. Comparison of somatic mutations shared...
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