Epigenetic Link Between Statin Therapy and Type 2 Diabetes.

doi:10.2337/dc19-1828

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Article

Epigenetic Link Between Statin Therapy and Type 2 Diabetes.

Diabetes care - 1 Apr 2020

Ochoa-Rosales Carolina, Portilla-Fernandez Eliana, Nano Jana, Wilson Rory, Lehne Benjamin, Mishra Pashupati P, Gao Xu, Ghanbari Mohsen, Rueda-Ochoa Oscar L, Juvinao-Quintero Diana, Loh Marie, Zhang Weihua, Kooner Jaspal S, Grabe Hans J, Felix Stephan B, Schöttker Ben, Zhang Yan, Gieger Christian, Müller-Nurasyid Martina, Heier Margit, Peters Annette, Lehtimäki Terho, Teumer Alexander, Brenner Hermann, Waldenberger Melanie, Ikram M Arfan, van Meurs Joyce B J, Franco Oscar H, Voortman Trudy, Chambers John, Stricker Bruno H, Muka Taulant

Abstract excerpt

OBJECTIVE: To investigate the role of epigenetics in statins' diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood. RESEARCH DESIGN AND METHODS: Five cohort studies' participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32033992
DOI: 10.2337/dc19-1828

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