Article
Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.
International journal of immunogenetics - 1 Jun 2021
Antunes Andrade Fabiana, Goeldner Eibofner Isabela, Pieczarka Cristhine, van Tong Hoang, Sena Leia, Skare Thelma, Ramos da Rosa Utiyama Shirley, Jose de Messias-Reason Iara, P Velavan Thirumalaisamy
Abstract excerpt
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
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