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Mitochondrial DNA mutations do not impact early human embryonic development.

Mitochondrion - 1 May 2021

Chatzovoulou Kalliopi, Mayeur Anne, Gigarel Nadine, Jabot-Hanin Fabienne, Hesters Laetitia, Munnich Arnold, Frydman Nelly, Bonnefont Jean-Paul, Steffann Julie

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited disorders, although mechanisms regulating mother-to-offspring transmission have not yet been elucidated. To investigate if mtDNA mutations affect embryonic development, we compared morphology, viability and mtDNA content in control (n = 165) and mitochondrial (n = 16) human embryos at the cleavage-stage. mtDNA copy number (CN) was assessed in...

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PMID: 33639270
DOI: 10.1016/j.mito.2021.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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