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Associations of young onset age and genetic risk of beta cell dysfunction with glycaemic progression in individuals with type 2 diabetes.

Diabetes & metabolism - 1 Nov 2021

Liu J-J, Gurung R L, Liu S, Yiamunaa M, Lee J, Ang K, Tavintharan S, Tang W E, Sum C F, Lim S-C

Abstract excerpt

AIM: To study the relationship between genetic risk of beta cell dysfunction, young onset age and glycaemic progression in individuals with type 2 diabetes (T2D). MATERIALS AND METHODS: 1385 T2D outpatients were included in cross-sectional sub-study and 730 insulin-naïve outpatients were followed for 3 years in prospective sub-study. Genetic risk score (GRS) was derived from 24 beta cell dysfunction-related...

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PMID: 33636360
DOI: 10.1016/j.diabet.2021.101238

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