Article
In silico screening and identification of deleterious missense SNPs along with their effects on CD-209 gene: An insight to CD-209 related-diseases.
PloS one - 1 Jan 2021
Kakar Mohib Ullah, Matloob Muhammad, Dai Rongji, Deng Yulin, Ullah Kifayat, Kakar Ihsan Ullah, Khaliq Ghulam, Umer Muhammad, Bhutto Zhoaib Ahmed, Fazlani Sarfarz Ali, Mehboob Muhammad Zubair
Abstract excerpt
DC-SIGN receptor articulated by macrophages and dendritic cells is encoded by CD209 gene and plays a role to activate and proliferate the T-lymphocytes in response of virus attack. The dysfunctional activity of DC-SIGN receptor because of missense SNPs can lead to cause dengue haemorrhage fever, HIV-1 infection etc. Out of 11 transcripts of CD209, all missense SNPs of canonical transcript were retrieved from...
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