Article
Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X.
PLoS genetics - 1 May 2009
Cheng Ching-Yu, Kao W H Linda, Patterson Nick, Tandon Arti, Haiman Christopher A, Harris Tamara B, Xing Chao, John Esther M, Ambrosone Christine B, Brancati Frederick L, Coresh Josef, Press Michael F, Parekh Rulan S, Klag Michael J, Meoni Lucy A, Hsueh Wen-Chi, Fejerman Laura, Pawlikowska Ludmila, Freedman Matthew L, Jandorf Lina H, Bandera Elisa V, Ciupak Gregory L, Nalls Michael A, Akylbekova Ermeg L, Orwoll Eric S, Leak Tennille S, Miljkovic Iva, Li Rongling, Ursin Giske, Bernstein Leslie, Ardlie Kristin, Taylor Herman A, Boerwinckle Eric, Zmuda Joseph M, Henderson Brian E, Wilson James G, Reich David
Abstract excerpt
The prevalence of obesity (body mass index (BMI) > or =30 kg/m(2)) is higher in African Americans than in European Americans, even after adjustment for socioeconomic factors, suggesting that genetic factors may explain some of the difference. To identify genetic loci influencing BMI, we carried out a pooled analysis of genome-wide admixture mapping scans in 15,280 African Americans from 14 epidemiologic studies....
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