Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention.

Clinical epigenetics - 25 Feb 2021

Tellez Carmen S, Picchi Maria A, Juri Daniel, Do Kieu, Desai Dhimant H, Amin Shantu G, Hutt Julie A, Filipczak Piotr T, Belinsky Steven A

Abstract excerpt

BACKGROUND: Trimethylation of lysine 27 and dimethylation of lysine 9 of histone-H3 catalyzed by the histone methyltransferases EZH2 and G9a impede gene transcription in cancer. Our human bronchial epithelial (HBEC) pre-malignancy model studied the role of these histone modifications in transformation. Tobacco carcinogen transformed HBEC lines were characterized for cytosine DNA methylation, transcriptome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Biphenyl Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Assembly and Disassembly

Share to Enhancer of Zeste Homolog 2 Protein

Share to Histone Code

Share to Histone Methyltransferases

Share to Morpholines

Share to Pyridones

Source

Open in PubMed Open full text

Identifiers

PMID: 33632299
DOI: 10.1186/s13148-021-01034-4
PMCID: PMC7908796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention.PMID 33632299Read ↗

An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injurySemantic proximity Read ↗

Epithelial-mesenchymal transition and FOXA genes during tobacco smoke carcinogen induced transformation of human bronchial epithelial cellsSemantic proximity Read ↗

Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma.Semantic proximity Read ↗

Epigenomic targets for the treatment of respiratory diseaseSemantic proximity Read ↗

An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.Semantic proximity Read ↗

Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2.Semantic proximity Read ↗

DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2Semantic proximity Read ↗

Targeting EZH2 in cancer.Semantic proximity Read ↗

Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung CancerSemantic proximity Read ↗

EZH2 endorses cell plasticity to carcinoma cells facilitating mesenchymal to epithelial transition and tumour colonizationSemantic proximity Read ↗

EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axisSemantic proximity Read ↗

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.