Article
Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2005
Hofer Anne C, Tran Rosie T, Aziz Owais Z, Wright Woodring, Novelli Giuseppe, Shay Jerry, Lewis Marc
Abstract excerpt
Segmental progeroid syndromes are those whose phenotypes resemble accelerated aging. Here we analyze those phenotypes and hypothesize that short telomeres produce the same group of symptoms in a variety of otherwise unrelated progeroid syndromes. Specific findings are the following: (a) short telomeres in some progeroid syndromes cause an alopecia/osteoporosis/fingernail-atrophy group of symptoms; (b) fingernail...
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