Article
Identification of New Candidate Vaccine Antigens Made byStreptococcus pyogenes:Purification and Characterization of 16 Putative Extracellular Lipoproteins
1 Jan 2004
Abstract excerpt
Putative extracellular lipoproteins made by group A Streptococcus (GAS) are the focus of this study, which was designed to identify new candidate vaccine antigens. Bioinformatic analysis of a serotype M1 GAS strain identified 30 open-reading frames encoding putative lipoproteins. The genes encoding the mature form of 29 of these proteins were cloned, and 16 recombinant proteins were overexpressed in Escherichia...
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