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Article

Hepatitis E virus ORF 1 induces proliferative and functional T-cell responses in patients with ongoing and resolved hepatitis E.

Liver international : official journal of the International Association for the Study of the Liver - 1 Feb 2018

Al-Ayoubi Jana, Behrendt Patrick, Bremer Birgit, Suneetha Pothakamuri Venkata, Gisa Anett, Rinker Franziska, Manns Michael P, Cornberg Markus, Wedemeyer Heiner, Kraft Anke R M

Abstract excerpt

BACKGROUND AND AIMS: Hepatitis E virus (HEV) is a major cause of acute viral hepatitis with >3 million symptomatic cases per year accounting for 70 000 HEV-related deaths. HEV-specific T-cell responses have been investigated against structural proteins expressed by open reading frames (ORF) 2 and 3. T-cell responses against non-structural HEV proteins encoded by ORF1 are hardly studied. The aim of this study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28718943
DOI: 10.1111/liv.13521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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