Article

Papillary thyroid carcinoma as first and isolated neoplastic disease in a Lynch syndrome family member with a germline MLH1 mutation

2022-02-18

Abstract excerpt

The Lynch syndrome (LS) is an autosomal dominant disorder characterized by a strongly increased risk of developing colorectal cancer and several extra-colonic malignancies, such as carcinomas of the endometrium, ovary, ureter, stomach, and small intestine [1]. Lynch syndrome is caused by germline mutations in mismatch repair genes (MMR)[2], mainly in MLH1 and MSH2 , rarely in MSH6 and PMS2 [3,4]. Tumors usually de...

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Literature Corpus work: ff6746fe-b4a1-5273-ac1c-40cdd1c6550a
DOI: 10.21203/rs.3.rs-1359534/v1

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