Article
A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex.
Journal of genetics and genomics = Yi chuan xue bao - 20 Dec 2020
Li Xiaoxue, Hu Tingdong, Liu Jiying, Fang Bin, Geng Xue, Xiong Qiang, Zhang Lining, Jin Yong, Liu Xiaorui, Li Lin, Wang Ying, Li Rongfeng, Bai Xiaochun, Yang Haiyuan, Dai Yifan
Abstract excerpt
Tuberous sclerosis complex (TSC) is a dominant genetic neurocutaneous syndrome characterized by multiple organ hamartomas. Although rodent models bearing a germline mutation in either TSC1 or TSC2 gene have been generated, they do not develop pathogenic lesions matching those seen in patients with TSC because of the significant differences between mice and humans, highlighting the need for an improved large...
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