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Article

Retina as a Model to Study In Vivo Transmission of α-Synuclein in the A53T Mouse Model of Parkinson's Disease.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Mammadova Najiba, Baron Thierry, Verchère Jérémy, Greenlee Justin J, Greenlee M Heather West

Abstract excerpt

Parkinson's disease is a neurodegenerative disorder characterized by accumulation of misfolded α-synuclein within the central nervous system (CNS). Retinal manifestations have been widely described as a prodromal symptom; however, we have a limited understanding of the retinal pathology associated with Parkinson's disease. The strong similarities between the retina and the brain and the accessibility of the...

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PMID: 33606207
DOI: 10.1007/978-1-0716-1008-4_5

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