Article
Acoustofluidic rotational tweezing enables high-speed contactless morphological phenotyping of zebrafish larvae.
Nature communications - 18 Feb 2021
Chen Chuyi, Gu Yuyang, Philippe Julien, Zhang Peiran, Bachman Hunter, Zhang Jinxin, Mai John, Rufo Joseph, Rawls John F, Davis Erica E, Katsanis Nicholas, Huang Tony Jun
Abstract excerpt
Modern biomedical research and preclinical pharmaceutical development rely heavily on the phenotyping of small vertebrate models for various diseases prior to human testing. In this article, we demonstrate an acoustofluidic rotational tweezing platform that enables contactless, high-speed, 3D multispectral imaging and digital reconstruction of zebrafish larvae for quantitative phenotypic analysis. The...
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