Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population.

doi:10.1371/journal.pgen.1009323

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Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population.

PLoS genetics - 1 Feb 2021

Yu Mullin Ho Chung, Chan Marcus Chun Yin, Chung Claudia Ching Yan, Li Andrew Wang Tat, Yip Chara Yin Wa, Mak Christopher Chun Yu, Chau Jeffrey Fong Ting, Lee Mianne, Fung Jasmine Lee Fong, Tsang Mandy Ho Yin, Chan Joshua Chun Ki, Wong Wilfred Hing Sang, Yang Jing, Chui William Chun Ming, Chung Patrick Ho Yu, Yang Wanling, Lee So Lun, Chan Godfrey Chi Fung, Tam Paul Kwong Hang, Lau Yu Lung, Tang Clara Sze Man, Yeung Kit San, Chung Brian Hon Yin

Abstract excerpt

Preemptive pharmacogenetic testing has the potential to improve drug dosing by providing point-of-care patient genotype information. Nonetheless, its implementation in the Chinese population is limited by the lack of population-wide data. In this study, secondary analysis of exome sequencing data was conducted to study pharmacogenomics in 1116 Hong Kong Chinese. We aimed to identify the spectrum of actionable...

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PMID: 33600428
DOI: 10.1371/journal.pgen.1009323
PMCID: PMC7891783

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