Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.

doi:10.1016/j.jmoldx.2016.01.003

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Article

Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade.

The Journal of molecular diagnostics : JMD - 1 May 2016

Ji Yuan, Skierka Jennifer M, Blommel Joseph H, Moore Brenda E, VanCuyk Douglas L, Bruflat Jamie K, Peterson Lisa M, Veldhuizen Tamra L, Fadra Numrah, Peterson Sandra E, Lagerstedt Susan A, Train Laura J, Baudhuin Linnea M, Klee Eric W, Ferber Matthew J, Bielinski Suzette J, Caraballo Pedro J, Weinshilboum Richard M, Black John L

Abstract excerpt

Significant barriers, such as lack of professional guidelines, specialized training for interpretation of pharmacogenomics (PGx) data, and insufficient evidence to support clinical utility, prevent preemptive PGx testing from being widely clinically implemented. The current study, as a pilot project for the Right Drug, Right Dose, Right Time-Using Genomic Data to Individualize Treatment Protocol, was designed to...

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PMID: 26947514
DOI: 10.1016/j.jmoldx.2016.01.003
PMCID: PMC4851731

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VKORC1

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