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DNA methylation and SNP in IFITM3 are correlated with hand, foot and mouth disease caused by enterovirus 71.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Apr 2021

Li Mei, Li Ya-Ping, Deng Hui-Ling, Wang Mu-Qi, Chen Yuan, Zhang Yu-Feng, Wang Jun, Dang Shuang-Suo

Abstract excerpt

OBJECTIVES: To explore the mechanisms of interferon-induced transmembrane protein 3 (IFITM3) in response to enterovirus-71-associated hand, foot and mouth disease (EV71-HFMD), in terms of DNA methylation, single-nucleotide polymorphism (SNP) genotype and gene expression. METHODS: In total, 120 patients with EV71-HFMD (60 with mild EV71-HFMD and 60 with severe EV71-HFMD) and 60 healthy controls were enrolled in...

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PMID: 33596480
DOI: 10.1016/j.ijid.2021.02.049

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