Article
Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition, and Implication of CDH23 in Schizophrenia.
Schizophrenia bulletin - 8 Jul 2021
Balan Shabeesh, Ohnishi Tetsuo, Watanabe Akiko, Ohba Hisako, Iwayama Yoshimi, Toyoshima Manabu, Hara Tomonori, Hisano Yasuko, Miyasaka Yuki, Toyota Tomoko, Shimamoto-Mitsuyama Chie, Maekawa Motoko, Numata Shusuke, Ohmori Tetsuro, Shimogori Tomomi, Kikkawa Yoshiaki, Hayashi Takeshi, Yoshikawa Takeo
Abstract excerpt
We previously identified quantitative trait loci (QTL) for prepulse inhibition (PPI), an endophenotype of schizophrenia, on mouse chromosome 10 and reported Fabp7 as a candidate gene from an analysis of F2 mice from inbred strains with high (C57BL/6N; B6) and low (C3H/HeN; C3H) PPI levels. Here, we reanalyzed the previously reported QTLs with increased marker density. The highest logarithm of odds score (26.66)...
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