microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.

doi:10.1038/s41467-021-21107-5

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Article

microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity.

Nature communications - 16 Feb 2021

Horie Takahiro, Nakao Tetsushi, Miyasaka Yui, Nishino Tomohiro, Matsumura Shigenobu, Nakazeki Fumiko, Ide Yuya, Kimura Masahiro, Tsuji Shuhei, Rodriguez Randolph Ruiz, Watanabe Toshimitsu, Yamasaki Tomohiro, Xu Sijia, Otani Chiharu, Miyagawa Sawa, Matsushita Kazuki, Sowa Naoya, Omori Aoi, Tanaka Jin, Nishimura Chika, Nishiga Masataka, Kuwabara Yasuhide, Baba Osamu, Watanabe Shin, Nishi Hitoo, Nakashima Yasuhiro, Picciotto Marina R, Inoue Haruhisa, Watanabe Dai, Nakamura Kazuhiro, Sasaki Tsutomu, Kimura Takeshi, Ono Koh

Abstract excerpt

Adaptive thermogenesis is essential for survival, and therefore is tightly regulated by a central neural circuit. Here, we show that microRNA (miR)-33 in the brain is indispensable for adaptive thermogenesis. Cold stress increases miR-33 levels in the hypothalamus and miR-33-/- mice are unable to maintain body temperature in cold environments due to reduced sympathetic nerve activity and impaired brown adipose...

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Identifiers

PMID: 33594062
DOI: 10.1038/s41467-021-21107-5
PMCID: PMC7886914

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