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Are functional variants of the microRNA-146a gene associated with primary knee OA? Evidence in Mexican mestizo population.

Molecular biology reports - 1 Feb 2021

Miranda-Duarte Antonio, Borgonio-Cuadra Verónica Marusa, González-Huerta Norma Celia, Rojas-Toledo Emma Xochitl, Ahumada-Pérez Juan Francisco, Morales-Hernández Eugenio, Pérez-Hernández Nonanzit, Rodríguez-Pérez José Manuel, Vargas-Alarcón Gilberto

Abstract excerpt

MicroRNA-146a (miR-146a) is an inflammatory response regulator whose expression is deregulated in osteoarthritis (OA); variations in the miR-146a gene could affect OA risk. This study aimed to analyze the association between two functional variants of the miR-146a gene and primary knee OA in Mexican mestizo population. Methods and Results. A case-control study was conducted with cases defined as individuals...

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PMID: 33590413
DOI: 10.1007/s11033-021-06207-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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