Mutation in the prion protein gene at codon 232 in Japanese patients with Creutzfeldt-Jakob disease: a clinicopathological, immunohistochemical and transmission study.

doi:10.1007/s004010050544

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Article

Mutation in the prion protein gene at codon 232 in Japanese patients with Creutzfeldt-Jakob disease: a clinicopathological, immunohistochemical and transmission study.

Acta neuropathologica - 1 Nov 1996

Hoque M Z, Kitamoto T, Furukawa H, Muramoto T, Tateishi J

Abstract excerpt

We describe the clinical, neuropathological, immunohistochemical and transmission findings in three patients with Creutzfeldt-Jakob disease (CJD) with a substitution from methionine to arginine at codon 232 (M232R) in the prion protein (PrP) gene. The patients with M232R presented clinically with...

Topics

Aged
Creutzfeldt-Jakob Syndrome
Female
Humans
Immunohistochemistry
Japan
Male
Middle Aged
Mutation
Prions

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