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Article

Systemic sclerosis skin is a primed microenvironment for soft tissue calcification-a hypothesis.

Rheumatology (Oxford, England) - 18 Jun 2021

Burgess Kyle A, Herrick Ariane L, Watson Rachel E B

Abstract excerpt

Calcinosis cutis, defined as sub-epidermal deposition of calcium salts, is a major clinical problem in patients with SSc, affecting 20-40% of patients. A number of recognized factors associated with calcinosis have been identified, including disease duration, digital ischaemia and acro-osteolysis. Yet, to date, the pathogenesis of SSc-related calcinosis remains unknown, and currently there is no effective...

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Source

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PMID: 33585894
DOI: 10.1093/rheumatology/keab156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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