Article
Functional phenotyping of the CYP2D6 probe drug codeine in the horse.
BMC veterinary research - 13 Feb 2021
Gretler S R, Finno C J, Kass P H, Knych H K
Abstract excerpt
BACKGROUND: In humans, the drug metabolizing enzyme CYP2D6 is highly polymorphic resulting in substantial differences in the metabolism of drugs including anti-arrhythmics, neuroleptics, and opioids. The objective of this study was to phenotype a population of 100 horses from five different breeds and assess differences in the metabolic activity of the equine CYP2D6 homolog using codeine as a probe drug....
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