Article
CHBP induces stronger immunosuppressive CD127+ M-MDSC via erythropoietin receptor.
Cell death & disease - 12 Feb 2021
Li Jiawei, Tu Guowei, Zhang Weitao, Zhang Yi, Zhang Xuepeng, Qiu Yue, Wang Jiyan, Sun Tianle, Zhu Tongyu, Yang Cheng, Rong Ruiming
Abstract excerpt
Erythropoietin (EPO) is not only an erythropoiesis hormone but also an immune-regulatory cytokine. The receptors of EPO (EPOR)2 and tissue-protective receptor (TPR), mediate EPO's immune regulation. Our group firstly reported a non-erythropoietic peptide derivant of EPO, cyclic helix B peptide (CHBP), which could inhibit macrophages inflammation and dendritic cells (DCs) maturation. As a kind of innate immune...
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