Article
IL-Y Aggravates Murine Chronic Graft-Versus-Host Disease by Enhancing T and B Cell Responses.
Frontiers in immunology - 1 Jan 2020
Wan Li, Jin Ziqi, Hu Bo, Lv Kangkang, Lei Lei, Liu Yonghao, Song Yuan, Zhu Ying, Gong Huanle, Xu Mimi, Du Yuanyuan, Xu Yang, Liu Haiyan, Wu Depei, Liu Yuejun
Abstract excerpt
IL-Y, a synthetic member of IL-12 cytokine family, was found to exert potent immunosuppressive effects by inhibiting the differentiation and activation of Th1 and Th17 cells. However, the role of IL-Y in the development of chronic graft-versus-host disease (cGVHD) remains unknown. Here, using murine models of scleroderma-like and lupus-like cGVHD, we examined the function of IL-Y in the pathogenesis of cGVHD by...
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